Multi-Peptide + HA Serum
A water-based peptide serum that targets signs of aging, elasticity, firmness, and smoothness.
A well-rounded peptide serum for people who want a multi-targeted anti-aging formula without jumping straight to stronger actives.
It packs 11+ peptide technologies into one affordable serum — a combination that would cost 3–4x the price from most premium brands. For someone building an anti-aging routine on a budget, this is the intelligent starting point.
After cleansing and toning, before moisturizer. Morning or evening — but if using acids or retinol, use peptide serum on the opposite routine (e.g., peptides in AM, actives in PM).
People in their late 20s–40s starting to focus on prevention and firmness. Someone who wants to address multiple aging concerns in one lightweight step without committing to retinol yet.
If you're layering it directly with AHAs or vitamin C — the acids degrade the peptides and you lose efficacy. Also not the move if your skin's primary concern is acne, not aging.
Peptides are among the most gentle anti-aging actives. If your skin feels overwhelmed, it's likely something else in the routine. The Buffet/Multi-Peptide serum rarely causes irritation.
- A gentle hydrating serum (HA 2% + B5) applied before it
- Niacinamide in the morning for tone and barrier support
- Retinol at night on alternate days for a complementary AM/PM anti-aging approach
Best For
- Early signs of aging
- Firmness
- Elasticity
- Smoother-looking skin
- Peptide-focused routines
- Hydration-supportive layering
How to Use
Apply after cleansing and before moisturizer. Avoid layering in the same routine with direct acids, strong vitamin C, or other conflicting actives if sensitivity is a concern.
Key Ingredients
Inhibits the SNARE protein complex that triggers muscle contractions involved in repetitive facial expressions. This mechanism theoretically reduces the formation of expression lines (forehead lines, crow's feet) with consistent use.
Works by modulating enkephalin receptors (opioid pathway) to reduce muscle contraction-triggering signals — a different mechanism from Argireline, allowing a synergistic approach when used together for expression line reduction.
Signals skin fibroblasts to produce more collagen and other extracellular matrix proteins. It works by mimicking the signals released when existing collagen degrades, triggering the skin's repair response.
Inhibits the overproduction of interleukins (inflammatory signaling molecules) that break down collagen and elastin during the aging process. Works synergistically with Palmitoyl Tripeptide-1 — one stimulates collagen production, the other prevents its excessive breakdown.
Stimulates the production of six extracellular matrix proteins: collagen I, III, and IV, fibronectin, hyaluronic acid, and laminin-5. Designed as a more comprehensive matrix-regenerating peptide than earlier Matrixyl generations.
Attracts moisture at multiple skin depths, helping to hydrate both the surface and deeper layers of the skin.
Soothes irritated skin, promotes skin cell renewal, smooths rough texture, and supports barrier recovery.
Ingredients to Note
May be a concern for some skin types. Tap to learn more.
May be a concern for some skin types. Tap to learn more.
Full Ingredient List
Aqua (Water), Glycerin, Lactococcus Ferment Lysate, Acetyl Hexapeptide-8, Pentapeptide-18, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-38, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Acetylarginyltryptophyl Diphenylglycine, Sodium Hyaluronate Crosspolymer, Sodium Hyaluronate, Allantoin, Glycine, Alanine, Serine, Valine, Isoleucine, Proline, Threonine, Histidine, Phenylalanine, Arginine, Aspartic Acid, Trehalose, Fructose, Glucose, Maltose, Urea, Sodium PCA, PCA, Lactic Acid, Citric Acid, Trisodium Ethylenediamine Disuccinate, Xanthan Gum, PPG-26-Buteth-26, Carbomer, Isoceteth-20, Polysorbate 20, Sodium Hydroxide, Ethoxydiglycol, 1,2-Hexanediol, Caprylyl Glycol, Phenoxyethanol
About This Product
Formerly known as Buffet, The Ordinary Multi-Peptide + HA Serum brings together over 11 advanced peptide technologies alongside multi-weight hyaluronic acid, allantoin, and amino acid NMF complex in a single comprehensive anti-aging serum. It's designed as a one-step peptide solution that addresses multiple pathways — signal peptides, neurotransmitter inhibitors, and matrix support peptides — simultaneously.